Relationship between Anti-Ds-DNA Antibodies and Abnormal Kidney Function Tests in Patients with Lupus Nephritis
نویسندگان
چکیده
منابع مشابه
Anti-DNA antibodies in the urine of lupus nephritis patients.
BACKGROUND It has previously been reported that patients with systemic lupus erythematosus (SLE) and glomerulonephritis do not have anti- (deoxyribonucleic acid) DNA antibodies in their urine. This finding was attributed to specific entrapment of anti-DNA antibodies by the immune complexes in the glomerular capillary walls. METHODS This phenomenon has been re-investigated as part of a study o...
متن کاملANTI-dsDNA ANTIBODIES AND LUPUS NEPHRITIS
NEPHRITIS Antibodies against DNA were described in 1957 by four independent research groups (1–4). Scientists at that time could not foresee that the discovery of antibodies to double-stranded DNA (dsDNA) would have an immense impact on our understanding of origin and regulation of autoimmunity in general, and more specifically on autoimmunemediated inflammation. Soon after their discovery, it ...
متن کاملRelationship between anti-dsDNA, anti-nucleosome and anti-alpha-actinin antibodies and markers of renal disease in patients with lupus nephritis: a prospective longitudinal study
INTRODUCTION Glomerulonephritis is a major cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE). Deposition of autoantibodies in the glomeruli plays a key role in the development of lupus nephritis (LN). Different groups have proposed that either anti-nucleosome antibodies or antibodies that bind the intrinsic renal antigen, alpha-actinin, are central to the path...
متن کاملEntrapment of anti-DNA antibodies in the kidney of patients with systemic lupus erythematosus.
Antibodies to single-stranded DNA (anti-ssDNA) and double-stranded DNA (anti-dsDNA) were determined in serum and urine of nine patients with systemic lupus erythematosus (SLE) presenting with heavy proteinuria (greater than 300 mg/dl), and the activity of anti-DNA antibodies was compared between paired serum and urine samples in each patient. The results were expressed by the anti-DNA activity ...
متن کاملAnti-dsDNA, anti-Sm antibodies, and the lupus anticoagulant: significant factors associated with lupus nephritis.
BACKGROUND Lupus nephritis (LN) is a common manifestation in patients with systemic lupus erythematosus (SLE). Autoantibodies and ethnicity have been associated with LN, but the results are controversial. OBJECTIVE To study the immunological and demographic factors associated with the development of LN. PATIENTS AND METHODS A retrospective case-control study of 127 patients with biopsy-prov...
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ژورنال
عنوان ژورنال: American Journal of Immunology
سال: 2016
ISSN: 1553-619X
DOI: 10.3844/ajisp.2016.37.42